Otologic Manifestation in IgG4-Related Systemic Disease

Otologic Manifestation in IgG4-Related Systemic Disease

IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-year-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pat...

Recurrent pleuritis: consider IgG4-related systemic disease.

Renal manifestations of IgG4-related systemic disease

While autoimmune pancreatitis (AIP) has been recognized since the first description by Sarles et al in 1961, its involvement of other organs has been recognized more recently. Now, some form of IgG4-related systemic disease (IgG4-RSD) has been described in nearly every organ system, including the liver, gallbladder, other gastrointestinal sites, kidney, salivary and lacrimal glands, orbit, brea...

IgG4-Related Autoimmune Prostatitis: Is It an Unusual or Underdiagnosed Manifestation of IgG4-Related Disease?

IgG4-related disease (IgG4-RD) encompasses a wide range of extrapancreatic manifestations. Albeit some are relatively well known, others such as autoimmune prostatitis remain poorly described. We present a 61-year-old Latin-American male with autoimmune pancreatitis (AIP) who presented with lower urinary tract symptoms (LUTS), normal prostate specific antigen (PSA) test, and prostate enlargemen...

Inflammatory aortic aneurysm: possible manifestation of IgG4-related sclerosing disease.

In this study, we investigate the hypothesis that IgG4-related autoimmune reaction is involved in the formation of inflammatory aortic aneurysms (IAA). We obtained 23 cases of IAA and 11 cases of atherosclerotic aortic aneurysms (AAA) as control group. We evaluated the expression of IgG4 in both IAA study cases and AAA control cases. In addition, immunohistochemical expression of C-Kit, CD21, C...